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TBK1-IN-2

TBK1-IN-2 (Compound A1) is a potent TBK1 inhibitor (IC50: 775 pM) . TBK1-IN-2 binds to TBK1 through stable hydrogen bonds and π-π stacking, inhibiting IRF3 phosphorylation. TBK1-IN-2 synergizes with TNF/IFNγ to enhance immune-mediated tumor cell death. TBK1-IN-2 can be used in cancer immunotherapy research[1].

Product Specifications

CAS Number

3075572-35-6

UNSPSC

12352005

Target

IKK

Related Pathways

NF-κB

Field of Research

Cancer

Smiles

COC1=C(OC)C=C2C(N=C(C3=NNC=C3NC(N4CCC(NC(OCC5=CC=CC=C5)=O)CC4)=O)N2)=C1

Molecular Formula

C26H29N7O5

Molecular Weight

519.55

References & Citations

[1]Sun W, et al. Structure-Based Optimization of TBK1 Inhibitors. ACS Med Chem Lett. 2025 Mar 31;16 (4) :611-616.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TBK1

Frequently Asked Questions

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