TBK1-IN-2
TBK1-IN-2 (Compound A1) is a potent TBK1 inhibitor (IC50: 775 pM) . TBK1-IN-2 binds to TBK1 through stable hydrogen bonds and π-π stacking, inhibiting IRF3 phosphorylation. TBK1-IN-2 synergizes with TNF/IFNγ to enhance immune-mediated tumor cell death. TBK1-IN-2 can be used in cancer immunotherapy research[1].
Product Specifications
CAS Number
[3075572-35-6]
UNSPSC
12352005
Target
IKK
Related Pathways
NF-κB
Field of Research
Cancer
Smiles
COC1=C(OC)C=C2C(N=C(C3=NNC=C3NC(N4CCC(NC(OCC5=CC=CC=C5)=O)CC4)=O)N2)=C1
Molecular Formula
C26H29N7O5
Molecular Weight
519.55
References & Citations
[1]Sun W, et al. Structure-Based Optimization of TBK1 Inhibitors. ACS Med Chem Lett. 2025 Mar 31;16 (4) :611-616.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TBK1
Curated Selection
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