Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

TBK1-IN-2

TBK1-IN-2 (Compound A1) is a potent TBK1 inhibitor (IC50: 775 pM) . TBK1-IN-2 binds to TBK1 through stable hydrogen bonds and π-π stacking, inhibiting IRF3 phosphorylation. TBK1-IN-2 synergizes with TNF/IFNγ to enhance immune-mediated tumor cell death. TBK1-IN-2 can be used in cancer immunotherapy research[1].

Product Specifications

CAS Number

3075572-35-6

UNSPSC

12352005

Target

IKK

Related Pathways

NF-κB

Field of Research

Cancer

Smiles

COC1=C(OC)C=C2C(N=C(C3=NNC=C3NC(N4CCC(NC(OCC5=CC=CC=C5)=O)CC4)=O)N2)=C1

Molecular Formula

C26H29N7O5

Molecular Weight

519.55

References & Citations

[1]Sun W, et al. Structure-Based Optimization of TBK1 Inhibitors. ACS Med Chem Lett. 2025 Mar 31;16 (4) :611-616.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TBK1

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

PEVR1 Antibody
8G722-AAT 50 µg

PEVR1 Antibody

Sign In for Pricing
View Details
FUNDC2 Human Gene Knockout Kit (CRISPR)
KN400793 1 Kit

FUNDC2 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
GLP1 (GCG) Rabbit Polyclonal Antibody
AP06137PU-N 100 µg

GLP1 (GCG) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
TentaGel® R PHB
R28013.5G 5 g

TentaGel® R PHB

Sign In for Pricing
View Details
MCAM / MUC18 / Mucin 18 / CD146 (MCAM/1101), CF405S conjugate, 0.1mg/mL
BNC041101-100 1x 100 µL

MCAM / MUC18 / Mucin 18 / CD146 (MCAM/1101), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
CEP104 Antibody
KC-23350-01 50 μL

CEP104 Antibody

Sign In for Pricing
View Details