N-0920
N-0920 is a potent TMPRSS2 inhibitor with an IC50 of 0.35 nM. N-0920 effectively inhibits SARS-CoV-2 variants EG.5.1 and JN.1 entry in Calu-3 cells, with picomolar EC50s values of 300 pM and 90 pM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(C2=NC=CS2)=O)=O)=O)OCC3=CC=CC=C3
Molecular Formula
C31H38N8O6S
Molecular Weight
650.75
References & Citations
[1]Lemieux G, et al. From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants. J Med Chem. 2025 Apr 10;68 (7) :7119-7136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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