NP1867
NP1867 is a potent, selective, covalent PMS2 inhibitor. NP1867 functionally inhibits DNA mismatch repair. NP1867 enhances immune surveillance. NP1867 can be used in the research of colorectal cancer[1][2].
Product Specifications
CAS Number
[2930070-08-7]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Inflammation/Immunology
Smiles
CN(C)C/C=C/C(NC1=C2C(CN(C2)C(C3=C(C(C)=C(C=C3O)O)OCC4CCCCC4)=O)=CC=C1)=O
Molecular Formula
C29H37N3O5
Molecular Weight
507.62
References & Citations
[1]Blagg J, et al. Abstract C086: NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples. Molecular Cancer Therapeutics, 2023, 22 (12_Supplement) : C086-C086. |[2]Piumatti E, et al. Pharmacological inhibition of PMS2 increases tumor mutational burden, induces microsatellite instability and elicits immune mediated rejection in vivo[J]. Cancer Research, 2024, 84 (6_Supplement) : 6011-6011.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173455/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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