AKR1C3-IN-15
AKR1C3-IN-15 (compound 30) is a potent and selective AKR1C3 inhibitor with an IC50 of 5 nM. AKR1C3-IN-15 enhances Sorafenib (HY-10201) -induced ROS generation, promoted apoptosis, and restored sorafenib sensitivity in HCC models both in vitro and in vivo[1].
Product Specifications
CAS Number
[3059671-44-9]
UNSPSC
12352005
Target
Aldose Reductase; Apoptosis
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(C=C(C=C2)F)OC1)N(CC3=CC=C(C=C3)C(O)=O)C
Molecular Formula
C19H16FNO4
Molecular Weight
341.33
References & Citations
[1]Xing S, et al. Discovery of Highly Potent AKR1C3 Inhibitors Treating Sorafenib-Resistant Hepatocellular Carcinoma. J Med Chem. 2025 Apr 10;68 (7) :7367-7389.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal 14-3-3 gamma [ac Val2] Antibody (KC21) [Alexa Fluor 350]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NB100-406AF350 0.1 mL
Mouse Monoclonal 14-3-3 gamma [ac Val2] Antibody (KC21) [Alexa Fluor 350]
Ask
View Details GTR15113391 1 Vial
Lentiviral human SNX30 shRNA (UAS) - Lentiviral human SNX30 shRNA (UAS, iRFP) (100)
Ask
View Details 
MBS6313406-01 0.2 mL
KIR2DS2, ID (KIR2DS2, CD158J, NKAT5, Killer cell immunoglobulin-like receptor 2DS2, CD158 antigen-like family member J, MHC class I NK cell receptor, NK receptor 183 ActI, Natural killer-associated transcript 5, p58 natural killer cell receptor clone CL-4
Ask
View Details MBS6313406-02 5x 0.2 mL
KIR2DS2, ID (KIR2DS2, CD158J, NKAT5, Killer cell immunoglobulin-like receptor 2DS2, CD158 antigen-like family member J, MHC class I NK cell receptor, NK receptor 183 ActI, Natural killer-associated transcript 5, p58 natural killer cell receptor clone CL-4
Ask
View Details