TAAR1/5-H-2CR agonist-1

TAAR1/5-H-2CR agonist-1 (compound 21b) is a TAAR1 and 5-HT2CR dual agonist with EC50s of 0.022 and 0.246 μM, respectively. TAAR1/5-H-2CR agonist-1 can used in the study of schizophrenia and Alzheimer's Disease[1].

Product Specifications

CAS Number

[3024777-79-2]

UNSPSC

12352005

Target

5-HT Receptor; Trace Amine-associated Receptor (TAAR)

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

N12CCNC[C@H]1C3=C(C=CS3)CC2

Molecular Formula

C10H14N2S

Molecular Weight

194.30

References & Citations

[1]Lu J, et al. Rational Design of the First Dual Agonist at Trace Amine-Associated Receptor 1 and 5-HT2C Receptors Based on Binding Pocket Similarity for the Treatment of Schizophrenia and Alzheimer's Disease-Related Psychosis. J Med Chem. 2025 Apr 10;68 (7) :7082-7105.