ZL0516

ZL0516 is a potent, selective, and orally active BRD4 BD1 inhibitor. ZL0516 suppresses inflammatory bowel disease (IBD) by inhibiting BRD4/NF-κB signaling[1].

Product Specifications

CAS Number

[2230496-93-0]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Related Pathways

Epigenetics

Field of Research

Inflammation/Immunology

Smiles

COC1=C2C(OC(C3=CC(C)=C(OC[C@H](O)CN4CCN(C)CC4)C(C)=C3)=CC2=O)=CC(OC)=C1

Molecular Formula

C27H34N2O6

Molecular Weight

482.57

References & Citations

[1]Ma Z, et al. Orally Bioavailable BRD4 BD1 Inhibitor ZL0516 Effectively Suppresses Colonic Inflammation in Animal Models of Inflammatory Bowel Disease. ACS Pharmacol Transl Sci. 2025 Apr 1;8 (4) :1152-1167.|[2]Lu J, et al. Rational Design of the First Dual Agonist at Trace Amine-Associated Receptor 1 and 5-HT2C Receptors Based on Binding Pocket Similarity for the Treatment of Schizophrenia and Alzheimer's Disease-Related Psychosis. J Med Chem. 2025 Apr 10;68 (7) :7082-7105.