ZL0516
ZL0516 is a potent, selective, and orally active BRD4 BD1 inhibitor. ZL0516 suppresses inflammatory bowel disease (IBD) by inhibiting BRD4/NF-κB signaling[1].
Product Specifications
CAS Number
2230496-93-0
UNSPSC
12352005
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Field of Research
Inflammation/Immunology
Smiles
COC1=C2C(OC(C3=CC(C)=C(OC[C@H](O)CN4CCN(C)CC4)C(C)=C3)=CC2=O)=CC(OC)=C1
Molecular Formula
C27H34N2O6
Molecular Weight
482.57
References & Citations
[1]Ma Z, et al. Orally Bioavailable BRD4 BD1 Inhibitor ZL0516 Effectively Suppresses Colonic Inflammation in Animal Models of Inflammatory Bowel Disease. ACS Pharmacol Transl Sci. 2025 Apr 1;8 (4) :1152-1167.|[2]Lu J, et al. Rational Design of the First Dual Agonist at Trace Amine-Associated Receptor 1 and 5-HT2C Receptors Based on Binding Pocket Similarity for the Treatment of Schizophrenia and Alzheimer's Disease-Related Psychosis. J Med Chem. 2025 Apr 10;68 (7) :7082-7105.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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