RIPK1-IN-30
RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. RIPK1-IN-30 exhibits protective effects in HT-29 cell model of TSZ-induced necroptosis with an EC50 of 6.77 μM[1].
Product Specifications
UNSPSC
12352005
Target
RIP kinase
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=CC(CN2C(N(C3=CC=CC(C(CC4=CC(OCCO5)=C5C=C4)=O)=C3)CCC2)=O)=C1
Molecular Formula
C27H25FN2O4
Molecular Weight
460.50
References & Citations
[1]Liu B, et al. Discovery and Characterization of Novel Receptor-Interacting Protein Kinase 1 Inhibitors Using Deep Learning and Virtual Screening. ACS Chem Neurosci. 2025 Apr 16;16 (8) :1617-1630.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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