CW-2
CW-2 is a PARP1 PROTAC degrader. CW-2 has potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and CDDP-resistant cells (A549/CDDP: IC50 = 3.52 μM). CW-2 has synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts antitumor effects by inducing DNA damage, impairing DNA repair, and activating mitochondria-dependent apoptosis (Pink: PARP1 ligand ; Blue: E3 CRBN ligand (HY-173439) ; Black: linker (HY-173440) ).
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis; PARP; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C1NN=C(C2=CC=CC=C21)CC3=CC(F)=C(C=C3)C(NCC(NC(CC4=CC=C(C=C4)OCC5=CN(N=N5)C6=C(C7=CC=C6)CN(C7=O)C8CCC(NC8=O)=O)C(O[Pt]([NH3])(Cl)(Cl)(O)[NH3])=O)=O)=O
Molecular Formula
C43H42Cl2FN11O10Pt
Molecular Weight
1157.85
References & Citations
[1]Li CX, et al. Pt (IV) -PROTAC Complexes with Synergistic Antitumor Activity and Enhanced Membrane Permeability. J Med Chem. 2025 Apr 24;68 (8) :8208-8225.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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