Dopamine D4 receptor ligand 3
Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pKi: 8.86) . Dopamine D4 receptor ligand 3 has pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells[1].
Product Specifications
CAS Number
3082344-46-2
UNSPSC
12352005
Target
Dopamine Receptor; Reactive Oxygen Species (ROS)
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CCC1=C2C=CC=C1)N2CCCN3CCN(CC3)C4=CC=C5C=CC=CC5=C4.O=C(O)C(O)=O
Molecular Formula
C28H31N3O5
Molecular Weight
489.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD63 (Late Endosomes Marker) (LAMP3/2789), CF568 conjugate, 0.1mg/mL
Recombinant Rat Tissue factor/TF protein (His tag)
Recombinant Rat Tissue factor/TF protein (His tag)