Dopamine D4 receptor ligand 3
Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pKi: 8.86) . Dopamine D4 receptor ligand 3 has pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells[1].
Product Specifications
CAS Number
[3082344-46-2]
UNSPSC
12352005
Target
Dopamine Receptor; Reactive Oxygen Species (ROS)
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CCC1=C2C=CC=C1)N2CCCN3CCN(CC3)C4=CC=C5C=CC=CC5=C4.O=C(O)C(O)=O
Molecular Formula
C28H31N3O5
Molecular Weight
489.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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