AD015
AD015 is a angiotensin-converting enzyme (ACE) and neprilysin (NEP) dual inhibitor. AD015 inhibits NEP, nACE and cACE with IC50s of 0.009, 0.019 and 0.0008 μM, respectively[1].
Product Specifications
CAS Number
177741-43-4
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Neprilysin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
S[C@@H](CC1=CC=CC=C1)C(NCC(N2[C@@H](C3=CC=C(C=C3)C)CC[C@H]2C(O)=O)=O)=O
Molecular Formula
C23H26N2O4S
Molecular Weight
426.53
References & Citations
[1]Cozier GE, et al. Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors. J Med Chem. 2025 Apr 10;68 (7) :7720-7736.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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