5-cis-15 (R) -Iloprost

5-cis-15 (R) -Iloprost (5-cis-15 (R) -Ciloprost) is the C-5 cis-isomer and 15 (R) -epimer of Iloprost (HY-A0096) . Iloprost is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research[1][2][3][4].

Product Specifications

Product Name Alternative

5-cis-15 (R) -Ciloprost; 5-cis-15 (R) -ZK 36374

UNSPSC

12352211

Target

Drug Isomer; Prostaglandin Receptor

Related Pathways

GPCR/G Protein; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Smiles

O[C@@H]1C[C@@]2([H])[C@]([C@H]1/C=C/[C@@H](C(CC#CC)C)O)([H])C/C(C2)=C\CCCC(O)=O

Molecular Formula

C22H32O4

Molecular Weight

360.49

References & Citations

[1]Kowalczyk-Zieba I, et al. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. 2020 Nov;157:286-296.|[2]Hildebrand M. Pharmacokinetics of iloprost and cicaprost in mice. Prostaglandins. 1992 Nov;44 (5) :431-42.|[3]Olave N, et al. Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315 (4) :L535-L544.|[4]Schneider MR, et al. Effects of prostacyclin analogues in in vivo tumor models. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:901-8.