Anti-inflammatory agent 100

Anti-inflammatory agent 100 (Compound (+) -4S-23) is an anti-inflammatory agent. Anti-inflammatory agent 100 inhibits MAPK and NF-κB signaling, and also inhibits NF-κB pathway by suppressing the phosphorylation of IκB-α and blocking nuclear translocation of phosphorylated p65. Anti-inflammatory agent 100 inhibits NO production (IC50: 0.5 μM) and TNF-α, IL-6, IL-1β secretion[1].

Product Specifications

UNSPSC

12352005

Target

ERK; JNK; NF-κB; p38 MAPK

Related Pathways

MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C1N2C(C(N(C)C([C@@H]2CC3=CC=CC=C3OCC=C)=O)=O)=NC4=CC=CC=C41

Molecular Formula

C22H19N3O4

Molecular Weight

389.40

References & Citations

[1]Zhou TY, et al. Semisynthesis and biological evaluation of 17-hydroxybrevianamide N derivatives as anti-inflammatory agents by mediating NF-κB and MAPK signaling pathways. Eur J Med Chem. 2025 Jun 5;290:117541.