Anti-inflammatory agent 100
Anti-inflammatory agent 100 (Compound (+) -4S-23) is an anti-inflammatory agent. Anti-inflammatory agent 100 inhibits MAPK and NF-κB signaling, and also inhibits NF-κB pathway by suppressing the phosphorylation of IκB-α and blocking nuclear translocation of phosphorylated p65. Anti-inflammatory agent 100 inhibits NO production (IC50: 0.5 μM) and TNF-α, IL-6, IL-1β secretion[1].
Product Specifications
UNSPSC
12352005
Target
ERK; JNK; NF-κB; p38 MAPK
Related Pathways
MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1N2C(C(N(C)C([C@@H]2CC3=CC=CC=C3OCC=C)=O)=O)=NC4=CC=CC=C41
Molecular Formula
C22H19N3O4
Molecular Weight
389.40
References & Citations
[1]Zhou TY, et al. Semisynthesis and biological evaluation of 17-hydroxybrevianamide N derivatives as anti-inflammatory agents by mediating NF-κB and MAPK signaling pathways. Eur J Med Chem. 2025 Jun 5;290:117541.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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