INOs-IN-6

INOs-IN-6 is an anti-inflammatory agent. iNOs-IN-6 inhibits NF-κB, iNOS, and MAPK expression (IC50: 0.2-0.62 μM) . iNOs-IN-6 reduces IL-6, TNF-α, and IL-1β pro-inflammatory mediators levels (IC50: 0.4-0.69 μM) [1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; NF-κB; NO Synthase; p38 MAPK

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Field of Research

Inflammation/Immunology

Smiles

ClC1=CC=C(NC(C2=C(C)NC(NC2C3=CC4=C(C=CC=C4)S3)=O)=O)C=C1

Molecular Formula

C20H16ClN3O2S

Molecular Weight

397.88

References & Citations

[1]Ahmed R. Ali, et al. Design, synthesis, and biological evaluation of new tetrahydropyrimidine derivatives as multitarget anti-inflammatory agents. European Journal of Medicinal Chemistry Reports. Volume 13, April 2025, 100259