AR antagonist 11

AR antagonist 11 (Compound c2) is a selective AR antagonist with an IC50 of 0.019 μM. AR antagonist 11 is also effective against ARF877L/T878A mutant (IC50: 1.03 μM) . AR antagonist 11 inhibits LNCaP cell proliferation and reduces PSA protein expression (IC50: 0.54 μM) . AR antagonist 11 can be used for research of prostate cancer (PCa) [1].

Product Specifications

CAS Number

[3005979-40-5]

UNSPSC

12352005

Target

Androgen Receptor; Ser/Thr Protease

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Smiles

ClC(C=C1)=CC=C1[C@@H]([C@@H]2[C@H]3OCC2)NC4=C3C5=CC=CN=C5C=C4

Molecular Formula

C20H17ClN2O

Molecular Weight

336.81

References & Citations

[1]Yuan L, et al. Discovery of novel tetrahydroquinoline derivatives as potent, selective, and orally Available AR antagonists. Eur J Med Chem. 2025 Jul 5;291:117566.