AR antagonist 11
AR antagonist 11 (Compound c2) is a selective AR antagonist with an IC50 of 0.019 μM. AR antagonist 11 is also effective against ARF877L/T878A mutant (IC50: 1.03 μM) . AR antagonist 11 inhibits LNCaP cell proliferation and reduces PSA protein expression (IC50: 0.54 μM) . AR antagonist 11 can be used for research of prostate cancer (PCa) [1].
Product Specifications
CAS Number
3005979-40-5
UNSPSC
12352005
Target
Androgen Receptor; Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
ClC(C=C1)=CC=C1[C@@H]([C@@H]2[C@H]3OCC2)NC4=C3C5=CC=CN=C5C=C4
Molecular Formula
C20H17ClN2O
Molecular Weight
336.81
References & Citations
[1]Yuan L, et al. Discovery of novel tetrahydroquinoline derivatives as potent, selective, and orally Available AR antagonists. Eur J Med Chem. 2025 Jul 5;291:117566.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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