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P2Y14R antagonist 4

P2Y14R antagonist 4 (Compound 25l) is an orally active P2Y14R antagonist (IC50: 5.6 nM) with superior binding affinity to P2Y14R over PPTN. P2Y14R antagonist 4 has anti-inflammatory activity and reduces LPS (HY-D1056) -induced proinflammatory cytokines (IL-1β, IL-6, and TNF-α) release[1].

Product Specifications

CAS Number

[3081687-67-1]

UNSPSC

12352005

Target

Interleukin Related; P2Y Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

OC(C1=CC(C2=CC=C(C3CCNCC3)C=C2)=CC(NS(CCC4=CC=C(C(F)(F)F)C=C4)(=O)=O)=C1)=O

Molecular Formula

C27H27F3N2O4S

Molecular Weight

532.57

References & Citations

[1]Ma S, et al. Discovery of a series of novel 3-sulfonamido benzoic acid derivatives as promising P2Y14R antagonists for acute lung injury. Eur J Med Chem. 2025 Jun 5;290:117588.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2Y14 Receptor

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