P2Y14R antagonist 4
P2Y14R antagonist 4 (Compound 25l) is an orally active P2Y14R antagonist (IC50: 5.6 nM) with superior binding affinity to P2Y14R over PPTN. P2Y14R antagonist 4 has anti-inflammatory activity and reduces LPS -induced proinflammatory cytokines (IL-1β, IL-6, and TNF-α) release[1].
Product Specifications
CAS Number
3081687-67-1
UNSPSC
12352005
Target
Interleukin Related; P2Y Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
OC(C1=CC(C2=CC=C(C3CCNCC3)C=C2)=CC(NS(CCC4=CC=C(C(F)(F)F)C=C4)(=O)=O)=C1)=O
Molecular Formula
C27H27F3N2O4S
Molecular Weight
532.57
References & Citations
[1]Ma S, et al. Discovery of a series of novel 3-sulfonamido benzoic acid derivatives as promising P2Y14R antagonists for acute lung injury. Eur J Med Chem. 2025 Jun 5;290:117588.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y14 Receptor
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