VB-85247

VB-85247 is a STING agonist. VB-85247 induces upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as maturation and activation of dendritic cells by activating the STING pathway. VB-85247 can achieve regression of intrabladder tumors and can be used in bladder cancer research[1].

Product Specifications

UNSPSC

12352005

Target

CXCR; IFNAR; Interleukin Related; STING; TNF Receptor

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C1NC(N)=NC2=C1N=CN2[C@H]3[C@H](OP4(S[Na])=O)[C@H](F)[C@@H](COP(OCCN5C6=C(N=C5CO4)N=CN=C6)(S[Na])=O)O3

Molecular Formula

C18H18FN9Na2O8P2S2

Molecular Weight

679.45

References & Citations

[1]Prabagar MG, et al. STING Agonist VB-85247 Induces Durable Antitumor Immune Responses by Intravesical Administration in a Non-Muscle-Invasive Bladder Cancer. Cancer Res. 2025 Apr 3;85 (7) :1287-1296.