VB-85247
VB-85247 is a STING agonist. VB-85247 induces upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as maturation and activation of dendritic cells by activating the STING pathway. VB-85247 can achieve regression of intrabladder tumors and can be used in bladder cancer research[1].
Product Specifications
UNSPSC
12352005
Target
CXCR; IFNAR; Interleukin Related; STING; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1NC(N)=NC2=C1N=CN2[C@H]3[C@H](OP4(S[Na])=O)[C@H](F)[C@@H](COP(OCCN5C6=C(N=C5CO4)N=CN=C6)(S[Na])=O)O3
Molecular Formula
C18H18FN9Na2O8P2S2
Molecular Weight
679.45
References & Citations
[1]Prabagar MG, et al. STING Agonist VB-85247 Induces Durable Antitumor Immune Responses by Intravesical Administration in a Non-Muscle-Invasive Bladder Cancer. Cancer Res. 2025 Apr 3;85 (7) :1287-1296.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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