TrxR-IN-8
TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC50: 10.2 μM) . TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells[1].
Product Specifications
CAS Number
2857180-28-8
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS) ; TrxR
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=CC(OC)=CC2=C1C3=C(C=[N+]2C)C=CC=C3.[I-]
Molecular Formula
C16H16INO2
Molecular Weight
381.21
References & Citations
[1]Xu Q, et al. Structural simplification of quaternary benzophenanthridine alkaloids generating a candidate for the treatment of non-small cell lung cancer. Eur J Med Chem. 2025 Jun 5;290:117551.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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