TrxR-IN-8

TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC50: 10.2 μM) . TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells[1].

Product Specifications

CAS Number

[2857180-28-8]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS) ; TrxR

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC1=CC(OC)=CC2=C1C3=C(C=[N+]2C)C=CC=C3.[I-]

Molecular Formula

C16H16INO2

Molecular Weight

381.21

References & Citations

[1]Xu Q, et al. Structural simplification of quaternary benzophenanthridine alkaloids generating a candidate for the treatment of non-small cell lung cancer. Eur J Med Chem. 2025 Jun 5;290:117551.