TPS1-IN-1
TPS1-IN-1 (Compound O1) is a highly potent and broad-spectrum TPS1 inhibitor. TPS1-IN-1 with IC50s of 14.73 μM for MoTPS1 (TPS1 of M oryzae) and 59.99 μM for BcTPS1 (TPS1 of B cinerea), respectively. TPS1-IN-1 exerts a broad-spectrum fungicidal effect by interfering with spore germination, appressorium formation, and turgor pressure accumulation of fungi. TPS1-IN-1 has good safety and has the potential to be a novel fungicide candidate compound[1].
Product Specifications
UNSPSC
12352005
Target
Fungal
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
OC(C(C)(C)C)(N1CCN(S(=O)(C2=CC=C(OC(F)(F)F)C=C2)=O)CC1)CN3C=NC=N3
Molecular Formula
C19H26F3N5O4S
Molecular Weight
477.50
References & Citations
[1]Jiang Z, et al. Structural optimization and discovery of high effective isopropanolamine-based TPS1 inhibitors as promising broad-spectrum fungicide candidates. Eur J Med Chem. 2025 Jun 5;290:117553.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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