P-gp inhibitor 29

P-gp inhibitor 29 (41) is a highly potent P-gp inhibitor and apoptosis inducer, with an IC50 of 8.9 nM in Eca109/VCR cells. P-gp inhibitor 29 (41) can be used in the research for Esophageal Cancer[1].

Product Specifications

CAS Number

[3082344-99-5]

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

CN1C(CC2=CC(OC)=C(OS(=O)(C3=CC=CC=C3[N+]([O-])=O)=O)C=C2)C4=CC(OC)=C(OC)C=C4CC1

Molecular Formula

C26H28N2O8S

Molecular Weight

528.57

References & Citations

[1]Bo Xu, et al. Design, synthesis, and biological activity study of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives against multidrug resistance in Eca109/VCR cells. Eur J Med Chem. 2025 Jul 5:291:117542.