UNC8212

UNC8212 is a TAM kinase inhibitor. UNC8212 has potent inhibitory activity against MERTK and AXL (IC50: 1.5 nM and 1.3 nM, respectively), and also inhibits TYRO3 (IC50: 6.7 nM) . UNC8212 mediates polypharmacological properties by targeting the structurally diverse "back pocket" region of the TAM kinase family. UNC8212 binds tightly to TAM kinases and potently inhibits MERTK and AXL phosphorylation. UNC8212 has anti-tumor effects and can be used in cancer immunotherapy and tumor cell targeting research[1].

Product Specifications

UNSPSC

12352005

Target

TAM Receptor

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC(C)C(NC1=CC(C#CC2=CC=C(NC3=NC(N[C@@H]4CC[C@@H](O)CC4)=C(C(NC5CCN(C)CC5)=O)C=N3)C=C2)=NC=C1)=O

Molecular Formula

C34H42N8O3

Molecular Weight

610.75

References & Citations

[1]Hopkins MD, et al. Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors. Eur J Med Chem. 2025 Jun 5;290:117561.