HSTING activator-1
HSTING activator-1 (Compound 68) is a STING agonist. hSTING activator-1 can effectively activate multiple human STING variants (R232, H232, HAQ) with EC50 values of 56 nM, 89 nM and 51 nM, respectively. hSTING activator-1 activates the type I interferon pathway by directly binding to STING protein and stabilizing its conformation, promoting downstream IRF3 phosphorylation and cytokine release. hSTING activator-1 inhibits fibrosarcoma tumor growth and has potential in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
IFNAR; Interleukin Related; STING
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=CC=C(S[C@@H](C)C2=NN=C(C3=CC=C(F)C=C3)N24)C4=C1)NCC(O5)=CC6=C5C=CC=C6
Molecular Formula
C26H19FN4O2S
Molecular Weight
470.52
References & Citations
[1]Basu S, et al. Synthesis and structure-activity evaluation of a series of novel tricyclic STING activators. Eur J Med Chem. 2025 Jun 5;290:117577.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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