NMDAR antagonist 5

NMDAR antagonist 5 (Compound A17) is a multi-target antagonist against NMDAR and monoamine transporters (SERT、DAT and NET) . NMDAR antagonist 5 shows good NMDAR antagonistic potency (IC50 = 0.3 μM) and monoamine transporter activities (SERT IC50 = 1.1 μM、DAT IC50 = 0.7 μM、NET IC50 = 2.7 μM) . NMDAR antagonist 5 is highly safe and has low toxicity (hepatotoxicity and nephrotoxicity (IC50 > 100 μM) ; cardiotoxicity (IC50 = 24.5 μM) ) . NMDAR antagonist 5 has antidepressant effects and can be used in the study of depression[1].

Product Specifications

CAS Number

[3038464-68-2]

UNSPSC

12352005

Target

Dopamine Transporter; iGluR; Monoamine Transporter; Serotonin Transporter

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C1([C@]2(N3CCCC3)CC(C=NN4)=C4CC2)=CC=CC=C1

Molecular Formula

C17H21N3

Molecular Weight

267.37

References & Citations

[1]Zheng F, et al. Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression. Eur J Med Chem. 2025 Jul 5;291:117538.