β-Glucuronidase-IN-3

β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC50: 12.9 nM) . β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs) [1].

Product Specifications

CAS Number

[3081681-34-4]

UNSPSC

12352005

Target

Bacterial; β-glucuronidase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C1N(C2=CNN=C2)[Se]C3=CC=CC=C31

Molecular Formula

C10H7N3OSe

Molecular Weight

264.14

References & Citations

[1]Ying TT, et al. Optimized ebselen derivatives as novel potent Escherichia coli β-glucuronidase covalent allosteric inhibitors. Eur J Med Chem. 2025 Jun 5;290:117571.