β-Glucuronidase-IN-3
β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC50: 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan and nonsteroidal anti-inflammatory drugs (NSAIDs).
Product Specifications
CAS Number
3081681-34-4
UNSPSC
12352005
Target
Bacterial; β-glucuronidase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C1N(C2=CNN=C2)[Se]C3=CC=CC=C31
Molecular Formula
C10H7N3OSe
Molecular Weight
264.14
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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