VU0467319
VU0467319 (Compound VU319) is a highly selective and blood-brain-permeable, orally active M1 positive allosteric modulator (PAM) (EC50: 492 nM) . VU0467319 is selective (EC50 > 30 μM) versus M2-5 for both human and rat. VU0467319 improves cognitive impairment in Alzheimer's disease (AD) through central M1 muscarinic receptors. VU0467319 does not induce cholinergic adverse reactions and has potential in AD research[1].
Product Specifications
CAS Number
[1432438-14-6]
Product Name Alternative
VU319
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Concentration
10mM
Purity
98.53
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(CC2=C(F)C=C(C3=CC=CC4=NN(C)C=C43)C=C2F)CC5=NC=CC=C51
Molecular Formula
C22H16F2N4O
Molecular Weight
390.39
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MAChR1
Available Sizes
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