MAO-B-IN-43
MAO-B-IN-43 (4) is a potent hMAO-B inhibitor and a weak GSK3β kinase inhibitor, with Ki values of 0.044 μM and 0.004 μM for hMAO-A and hMAO-B, respectively. MAO-B-IN-43 (4) can be used for the research of neurodegenerative disorder[1].
Product Specifications
UNSPSC
12352005
Target
GSK-3; Monoamine Oxidase
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C1C2=CN=C(NC3=CC=C(Cl)C(Cl)=C3)N=C2CCC1
Molecular Formula
C14H11Cl2N3O
Molecular Weight
308.16
References & Citations
[1]Maria Luisa Di Paolo, et al. 2- (Phenylamino) -7,8-dihydroquinazolin-5 (6H) -one, a promising scaffold for MAO-B inhibitors with potential GSK3β targeting. Eur J Med Chem. 2025 Jul 5:291:117580.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β; MAO-A; MAO-B
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