HCAIX/XII-IN-15

HCAIX/XII-IN-15 (Compound 17β) is an inhibitor of hCA IX and hCA XII, with Kis of 0.42 and 4.37 μM respectively. hCAIX/XII-IN-15 has pro-apoptotic effect in multiple myeloma cells[1].

Product Specifications

CAS Number

[69141-46-4]

UNSPSC

12352005

Target

Apoptosis; Carbonic Anhydrase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=S(C1=CC=C(C)C=C1)(OC2=CC(C(C)C)=CC=CC2=O)=O

Molecular Formula

C17H18O4S

Molecular Weight

318.39

References & Citations

[1]Melfi F, et al. O-derivatization of natural tropolone and β-thujaplicin leading to effective inhibitors of human carbonic anhydrases IX and XII. Eur J Med Chem. 2025 Jun 5;290:117552.