LXRα agonist 1
LXRα agonist 1 (Compound 40) is a selective LXRα agonist (EC50: 42 nM). LXRα agonist 1 also has a certain agonistic effect on LXRβ (EC50: 266 nM). LXRα agonist 1 promotes target gene transcription by stabilizing the ligand binding domain (LBD) of LXRα. LXRα agonist 1 exhibits potent antitumor effects in hepatocellular carcinoma cells when combined with the Raf inhibitor Sorafenib. LXRα agonist 1 can be used in the study of lipotoxic cancers[1].
Product Specifications
CAS Number
1790089-97-2
UNSPSC
12352005
Target
LXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C(C1=CC=CC=C1)=C2NC3=CC=C(N4CCCCC4)C=C3)N(CC5=CC=CC=C5)C2=O
Molecular Formula
C28H27N3O2
Molecular Weight
437.53
References & Citations
[1]Galvez B Pedreira J, et al. Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies. J Med Chem. 2025 Apr 10;68 (7) :7180-7196.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC682489-500 1x 500 µL
P21WAF1 (Tumor Suppressor Protein) (CIP1/2489R), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472720-100 1x 100 µL
PDCD1 / PD1 / CD279 (Programmed Cell Death 1) (PDCD1/2720), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
![PE Rat IgG2a, κ Isotype Control[2A3]](https://cdn.genprice.uk/products/763/68dd14b3061270361e7d454b/imageurl/e-ab-f09832d.webp)