LXRα agonist 1
LXRα agonist 1 (Compound 40) is a selective LXRα agonist (EC50: 42 nM) . LXRα agonist 1 also has a certain agonistic effect on LXRβ (EC50: 266 nM) . LXRα agonist 1 promotes target gene transcription by stabilizing the ligand binding domain (LBD) of LXRα. LXRα agonist 1 exhibits potent antitumor effects in hepatocellular carcinoma cells when combined with the Raf inhibitor Sorafenib (HY-10201) . LXRα agonist 1 can be used in the study of lipotoxic cancers[1].
Product Specifications
CAS Number
[1790089-97-2]
UNSPSC
12352005
Target
LXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C(C1=CC=CC=C1)=C2NC3=CC=C(N4CCCCC4)C=C3)N(CC5=CC=CC=C5)C2=O
Molecular Formula
C28H27N3O2
Molecular Weight
437.53
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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