4-Hydroxy nonenal glutathione (TFA)

4-Hydroxy nonenal glutathione (4-HNE-GSH) TFA is the primary metabolite of 4-Hydroxy-2-nonenal. 4-Hydroxy nonenal glutathionea TFA is a marker of oxidative stress in rat liver and hepatocytes. 4-Hydroxy nonenal glutathione TFA efficiently prevents formation of DNA adducts with 4-Hydroxy-2-nonenal in human cells[1][2][3].

Product Specifications

Product Name Alternative

4-HNE-GSH (TFA)

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C([C@H](NC(CC[C@@H](C(O)=O)N)=O)CSC1CC(OC1CCCCC)O)NCC(O)=O.FC(C(O)=O)(F)F

Molecular Formula

C21H34F3N3O10S

Molecular Weight

577.57

References & Citations

[1]Siems W, et al. Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes. Arch Biochem Biophys. 2010 Nov 15;503 (2) :248-52.|[2]Völkel W, et al. Glutathione conjugates of 4-hydroxy-2 (E) -nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats. Free Radic Biol Med. 2005 Jun 1;38 (11) :1526-36. |[3]Falletti O, et al. Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells. Free Radic Biol Med. 2007 Apr 15;42 (8) :1258-69.