DOTAGA-FAP-2286-ALB
DOTAGA-FAP-2286-ALB is a derivative of Rofapitide tetraxetan. DOTAGA-FAP-2286-ALB is a selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 67.5 nM. DOTAGA-FAP-2286-ALB enhances tumor retention via albumin interaction, prolonging blood circulation and improving radiometal complex stability (e.g., with 111In and 225Ac). DOTAGA-FAP-2286-ALB is promising for research of radionuclide therapy (TRT) of FAP-positive solid tumors[1].
Product Specifications
UNSPSC
12352005
Target
Drug Derivative; FAP
Related Pathways
Immunology/Inflammation; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC[C@@H](C(N[C@H](C(O)=O)CCCCNC(CCCC1=CC=C(I)C=C1)=O)=O)NC(CCC(C(O)=O)N2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)NCCSCC3=CC(CSC[C@@H](C(N4[C@H](C(N5[C@H](C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@H]6CC7=CC=CC=C7)=O)CCC(N)=O)=O)=O)CCC5)=O)CCC4)=O)NC(CCCCC)=O)=CC(CSC[C@@H](C(O)=O)NC6=O)=C3
Molecular Formula
C91H131IN16O25S3
Molecular Weight
2072.21
References & Citations
[1]Saito K, et al. Preclinical Characterization of Novel FAP-2286-Based Radioligand with Albumin Binder for Improved Tumor Retention. ACS Med Chem Lett. 2025 Mar 24;16 (4) :596-601.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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