PROTAC AR Degrader-10
PROTAC AR Degrader-10 (GT19) is a protein degrader targeting the androgen receptor (AR) with a DC50 value ≤100 nM. PROTAC AR Degrader-10 can be used for prostate cancer study. (Structure Note: Pink: target protein ligand ; Blue: E3 ligase ligand (HY-138793) ; Black: linker).
Product Specifications
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=C(C#N)C=CC(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCN(CCCSC5=CC=C(C(N(C6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)N=C3)=O)C2(C)C)=C1
Molecular Formula
C41H46ClN7O5S
Molecular Weight
784.37
References & Citations
[1]Zhang L, et al. Predicting PROTAC-targeted Degradation and Designing Androgen Receptor Degraders with AiPROTAC. Posted March 02, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Frequently Asked Questions
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