DGEM3
DGEM3 is a molecular glue degrader targeting GEMIN3 (a member of the survival of motor neuron complex) . dGEM3 can be used in the research of diseases related to abnormal protein regulation, such as cancer and neurodegenerative diseases[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer; Neurological Disease
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(Cl)C=C(Cl)C=C3)C=C2)=O)C[C@@H](O)C1)=O)C4=C5N(N=C4)CCCO5
Molecular Formula
C31H35Cl2N5O5
Molecular Weight
628.55
References & Citations
[1]Bushman J W, et al. Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq[J]. bioRxiv, 2025: 2025.03. 19.644003.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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