EB-TCIP

EB-TCIP (BAK-04-212) is a bivalent molecule comprised of AP1867 and BI-3812 (HY-111381). EB-TCIP can form a reversible ternary complex between FKBPF36V and BCL6BTB. EB-TCIP recruits FKBP12F36V-tagged EWS/FLI1 to DNA sites bound by the transcriptional regulator BCL6, leading to rapid expression of BCL6 target genes (eg: SOCS2 and CXCL11). EWS/FLI1 is a fusion transcription factors in Ewing sarcoma. EB-TCIP can be used for research of deregulated transcription in cancer[1].

Product Specifications

Product Name Alternative

BAK-04-212

UNSPSC

12352005

Target

BCL6

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(OC)C(OC)=CC([C@@H](C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(NCCCCCCNC(C4CCN(C5=NC(NC6=CC(C=C(OCC(NC)=O)C(N7C)=O)=C7C(OC)=C6)=C(Cl)C=N5)CC4)=O)=O)CCC8=CC=C(OC)C(OC)=C8)=O)=O)CC)=C1

Molecular Formula

C68H86ClN9O15

Molecular Weight

1304.91

References & Citations

[1]Bond MJ, et al. Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643353.