PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an inhibitor of phosphodiesterase 10A (PDE10A) with oral activity, and its IC50 value is 3.5 nM. PDE10A-IN-5 exerts the activity of inhibiting pulmonary vascular remodeling by inhibiting PDE10A and activating the cyclic adenosine monophosphate (cAMP) -associated signaling pathway, and can be used for research in the field of pulmonary arterial hypertension[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(C2CN(C3=NC4=CC=CC=C4C(C(NCCN(CC)CC)=O)=C3)C2)N=C5C=CC=CN51)OCC
Molecular Formula
C29H34N6O3
Molecular Weight
514.62
References & Citations
[1]Huang H, et al. Discovery of novel azetidine-based imidazopyridines as selective and orally bioavailable inhibitors of phosphodiesterase 10A for the treatment of pulmonary arterial hypertension. Eur J Med Chem. 2025 Jun 5;290:117537.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10
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