PDE10A-IN-5

PDE10A-IN-5 (Compound A30) is an inhibitor of phosphodiesterase 10A (PDE10A) with oral activity, and its IC50 value is 3.5 nM. PDE10A-IN-5 exerts the activity of inhibiting pulmonary vascular remodeling by inhibiting PDE10A and activating the cyclic adenosine monophosphate (cAMP) -associated signaling pathway, and can be used for research in the field of pulmonary arterial hypertension[1].

Product Specifications

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(C2CN(C3=NC4=CC=CC=C4C(C(NCCN(CC)CC)=O)=C3)C2)N=C5C=CC=CN51)OCC

Molecular Formula

C29H34N6O3

Molecular Weight

514.62

References & Citations

[1]Huang H, et al. Discovery of novel azetidine-based imidazopyridines as selective and orally bioavailable inhibitors of phosphodiesterase 10A for the treatment of pulmonary arterial hypertension. Eur J Med Chem. 2025 Jun 5;290:117537.