TYK2 ligand 2

TYK2 ligand 2 is a TYK2 ligand for TYD-68 (HY-173357) . TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 can be used in the study of psoriasis[1].

Product Specifications

CAS Number

[2924460-80-8]

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

COC1=C(C=CC=C1C2=NC=C(C=N2)F)NC3=CC(NC4=CC=C(C=N4)C(O)=O)=NC=C3C(NC)=O

Molecular Formula

C24H20FN7O4

Molecular Weight

489.46

References & Citations

[1]Xiong S, et al. Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model. J Med Chem. 2025 Apr 10;68 (7) :7560-7578.