TYD-68

TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359) ; Black: Linker (HY-W007732B) ; Blue: E3 ligase ligand (HY-14658) ; E3 ligase ligand + Linker (HY-173358) ) [1].

Product Specifications

UNSPSC

12352005

Target

JAK; PROTACs; STAT

Related Pathways

Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C=CC=C1C2=NC=C(C=N2)F)NC3=CC(NC4=CC=C(C=N4)C(NC5CCC(CC5)NC6=CC7=C(C=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O)=NC=C3C(NC)=O

Molecular Formula

C43H40FN11O7

Molecular Weight

841.85

References & Citations

[1]Xiong S, et al. Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model. J Med Chem. 2025 Apr 10;68 (7) :7560-7578.