TYD-68
TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359) ; Black: Linker (HY-W007732B) ; Blue: E3 ligase ligand (HY-14658) ; E3 ligase ligand + Linker (HY-173358) ) [1].
Product Specifications
UNSPSC
12352005
Target
JAK; PROTACs; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(C=CC=C1C2=NC=C(C=N2)F)NC3=CC(NC4=CC=C(C=N4)C(NC5CCC(CC5)NC6=CC7=C(C=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O)=NC=C3C(NC)=O
Molecular Formula
C43H40FN11O7
Molecular Weight
841.85
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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