Antiparasitic agent-26
Antiparasitic agent-26 (Compound 8) is an antiparasitic compound that potently inhibits the growth of Naegleria fowleri, with IC50 values of 22.87 μM (trophozoite stage) and 25.16 μM (cyst stage) . Antiparasitic agent-26 exerts its antiparasitic activity by inducing programmed cell death, including cytoplasmic calcium accumulation, mitochondrial membrane potential collapse, ATP synthesis inhibition, ROS accumulation, and chromatin condensation. Antiparasitic agent-26 can be used in the research of primary amoebic meningoencephalitis (PAM) [1].
Product Specifications
UNSPSC
12352005
Target
Parasite; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection; Inflammation/Immunology
Smiles
CC1=CC(OC(OC2=CC=C([N+]([O-])=O)C=C2)=O)=C(C(C)C)C=C1
Molecular Formula
C17H17NO5
Molecular Weight
315.32
References & Citations
[1]Ben Youssef M, et al. Amoebicidal thymol analogues against brain-eating amoeba, Naegleria fowleri. Bioorg Chem. 2025 Mar 6;159:108346.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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