HDHODH-IN-17
HDHODH-IN-17 (Compound 10) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.188 μM. hDHODH-IN-17 is in good agreement with the hDHODH activity pocket and interacted well with amino acid residues. hDHODH-IN-17 is the potential broad-spectrum antiviral agent[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
FC1=CC(C(O)=O)=C(/N=C2NC(/C(S\2)=C/C3=C(C=CC=C4)C4=CC=C3)=O)C=C1
Molecular Formula
C21H13FN2O3S
Molecular Weight
392.40
References & Citations
[1]Liu X, et, al. Discovery of a New Class of Thiazolidin-4-one-Based Inhibitors of Human Dihydroorotate Dehydrogenase: Biological Activity Evaluation, Molecular Docking, and Molecular Dynamics. ACS Omega. 2025 Mar 21;10 (12) :12393-12402.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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