HDHODH-IN-17

HDHODH-IN-17 (Compound 10) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.188 μM. hDHODH-IN-17 is in good agreement with the hDHODH activity pocket and interacted well with amino acid residues. hDHODH-IN-17 is the potential broad-spectrum antiviral agent[1].

Product Specifications

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

FC1=CC(C(O)=O)=C(/N=C2NC(/C(S\2)=C/C3=C(C=CC=C4)C4=CC=C3)=O)C=C1

Molecular Formula

C21H13FN2O3S

Molecular Weight

392.40

References & Citations

[1]Liu X, et, al. Discovery of a New Class of Thiazolidin-4-one-Based Inhibitors of Human Dihydroorotate Dehydrogenase: Biological Activity Evaluation, Molecular Docking, and Molecular Dynamics. ACS Omega. 2025 Mar 21;10 (12) :12393-12402.