ATXN1-MED15 PPI-IN-1
ATXN1-MED15 PPI-IN-1 (compound 5755483) is an inhibitor of ATXN1/MED15. ATXN1-MED15 PPI-IN-1 binds to ATXN1 residues 99-163 and inhibits both the interaction between ATXN1 and MED15, as well as the dimerization of polyQ-expanded ATXN1. ATXN1-MED15 PPI-IN-1 can be used for study of Spinocerebellar ataxia type 1[1].
Product Specifications
CAS Number
[420106-23-6]
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(/C=C/C1=CC=C(NC(C2=C(C3=CC=CC=C3C(O)=O)C=CC=C2)=O)C=C1)C4=CC=CC=C4
Molecular Formula
C29H21NO4
Molecular Weight
447.48
References & Citations
[1]Ioannis Gkekas, et al. Chemical targeting of the ATXN1 aa99-163 interaction site suppresses polyQ-expanded protein dimerization.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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