Ran-IN-1

Ran-IN-1 (Compound M36) is an orally active and selective Ran GTPase inhibitor. Ran-IN-1 binds to the GDP-bound form of Ran (RanGDP) at the allosteric switch II pocket with high specificity, stabilizing the inactive state and reducing the active Ran-GTP population. Ran-IN-1 induces apoptosis and represses DNA repair pathways like HR and NHEJ in epithelial ovarian cancer (EOC) cells. Ran-IN-1 is promising for research of EOC, particularly high-grade serous carcinoma[1].

Product Specifications

CAS Number

[2301869-11-2]

UNSPSC

12352005

Target

Apoptosis; Arf Family GTPase

Related Pathways

Apoptosis; GPCR/G Protein

Field of Research

Cancer

Smiles

FC1=CC=C(COC[C@@H]2[C@@H](OCC3=CC=C(F)C=C3)[C@@H](OCC4=CC=C(F)C=C4)[C@H](C(N)=S)O2)C=C1

Molecular Formula

C27H26F3NO4S

Molecular Weight

517.56

References & Citations

[1]Boudhraa Z, et al. Identification of a new inhibitor of Ran GTPase with therapeutic value in epithelial ovarian cancer[J]. bioRxiv, 2025: 2025.03. 02.641080.