BLINK15
BLINK15 is a BBB-penetrant CDK5 inhibitor. BLINK15 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 29.34 nM) and CDK5/p25 (IC50 = 12.08 nM) . BLINK15 offers anti-diabetic and neuroprotective benefits. BLINK15 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O[C@](C1=C(N2CC3=CC=CC=C3)C=CC(Br)=C1)(CC(C4=CC([N+]([O-])=O)=C(OC)C=C4)=O)C2=O
Molecular Formula
C24H19BrN2O6
Molecular Weight
511.32
References & Citations
[1]Paul S, et al, . A Cdk5 inhibitor restores cognitive function and alleviates type 2 diabetes in mice. iScience. 2025 Mar 11;28 (4) :112200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5; CDK9
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