BLINK11
BLINK11 is a BBB-penetrant CDK5 inhibitor. BLINK11 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 17.09 nM) and CDK5/p25 (IC50 = 14.69 nM) . BLINK11 offers anti-diabetic and neuroprotective benefits. BLINK11 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC=CC(Cl)=C1Cl)C2=CC=CC=C2OCC(NC3=CC=C(N4CCOCC4)C(Cl)=C3)=O
Molecular Formula
C25H22Cl3N3O4
Molecular Weight
534.82
References & Citations
[1]Paul S, et al, . A Cdk5 inhibitor restores cognitive function and alleviates type 2 diabetes in mice. iScience. 2025 Mar 11;28 (4) :112200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5; CDK9
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