SOF-436
SOF-436 is a KRAS inhibitor that inhibits SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and the binding of KRAS to the effector protein RAF. SOF-436 can be used in cancer research[1].
Product Specifications
CAS Number
2224491-20-5
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=S(C1=CC(S(F)(=O)=O)=CC=C1)(NC2=CC(F)=C(C3CC3)C=C2)=O
Molecular Formula
C15H13F2NO4S2
Molecular Weight
373.39
References & Citations
[1]Landgraf A, et al. Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation. ChemMedChem. 2025 Mar 18:e202400624.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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